Etiology and Types of Dengue Fever:
DENV belongs to the Flaviviridae family and exists in four distinct but closely related serotypes-DENV-1, DENV-2, DENV-3, and DENV-4. The mosquito borne disease mainly occurs in two forms. Dengue fever or break-bone fever is usually an uncomplicated and self-limited febrile illness affecting muscles and joints with severe back pain and myalgia.Dengue hemorrhagic fever (DHF), on the other hand, is an intense and potentially fatal form of acute febrile illness commonly seen in children under 15 years and is characterized by cutaneous and intestinal hemorrhages induced by thrombocytopenia, haemoconcentration, hypovolemic shock, and neurologic disturbances.
Dengue virus (DENV) mainly infects blood monocytes, lymphocytes, and endothelial cells, resulting in complement activation and consumptive coagulopathy, including thrombocytopenia. If left untreated, it can develop into dengue shock syndrome, eventually causing death.Despite the lack of definite treatment and preventive vaccination, early diagnosis and medical care access can vastly reduce the severe dengue fatality rate. In recent times, the global incidence of dengue has increased dramatically. Dengue viruses transported by the infected travelers increased the risk of developing the disease in the world population. However, effective vector control strategies to prevent the breeding of Dengue mosquitos can help in eradicating the disease.
Dengue Fever Symptoms and Signs:
Dengue is a flu-like viral infection affecting humans regardless of age. The patient experiences dengue symptoms such as high-grade fever accompanied by frontal headache, retro-orbital pain, myalgia, arthralgia, nausea and vomiting, hemorrhagic manifestations, swollen glands, leukopenia, and skin rashes. Furthermore, the primary medical complications of classic dengue fever are febrile seizures and severe dehydration.
Clinical Diagnosis of Dengue fever:
The presumptive diagnosis of dengue comprises physical examination, travel history to the dengue dengue-endemic regions, and clinical evidence of thrombocytopenia. Definitive diagnosis includes serological testing for dengue virus antibodies like dengue IgG (DENG) and dengue IgM (DENM). Additionally, a single-specimen rapid molecular diagnostic tool such as RT-PCR dengue test kits and enzyme-linked immunosorbent assay test detects dengue virus serotypes and dengue nonstructural protein 1 (NS1) antigen, respectively.
Insight to the Dengue Biospecimens We Offer:
Central BioHub offers a dedicated collection of human bio specimens of individuals suspected or confirmed with dengue fever. Our biobank contains dengue clinical samples, ethically isolated from consented donors of every age, gender, and ethnicity by complying with the declaration of Helsinki and Taipei to accelerate the research on dengue treatment.
Dengue patient samples include human biofluids like human saliva, urine, whole blood, serum, and plasma samples explicitly tested for various laboratory tests like DENV SubT, dengue NS-1 (DENG NS-1), and antibody testing for Dengue IgG and IgM stored at our biobank in perfect condition at <-18 or <-80 °Celsius. Accelerating indigenous dengue research, we provide small volume samples of dengue virus laboratory samples with detailed clinical data and country or regions of sample origin.
Central BioHub connects certified global biomaterial suppliers and Life science researchers or scientists through our virtual platform. Prioritizing quality and customer satisfaction, scientists worldwide can purchase indented superior quality human bio specimens online with complete assistance from our scientific experts at the Central BioHub.Hurry up, Procure Dengue fever samples online.
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