The pathogenic organism transmits from one person to another through unprotected sexual contact with infected mucous membranes or cutaneous lesions. On rare occasions, it can be acquired by nonsexual personal contact, accidental inoculation, or blood transfusions. Besides, syphilis disease may indeed be transmitted to a fetus from infected mothers. If not treated appropriately, syphilis may have serious health consequences.
Syphilis – Signs and Symptoms:
Clinical presentation of syphilis infection varies from person to person with progression through multiple syphilis stages, possibly in untreated or inadequately treated patients. Primary syphilis symptoms are characterized by the appearance of painless indurated lesions (syphilis rash or syphilis chancre) on the cutaneous or mucocutaneous tissue, especially on external genitalia. Secondary syphilis infection demonstrates multisystem involvement secondary to hematogenous and lymphatic spread manifested by pruritic or nonpruritic syphilis rash, mucocutaneous lesions, flu-like symptoms lymphadenopathy. In tertiary syphilis symptoms include widespread multiorgan infections resulting in cardiovascular syphilis, neurosyphilis, gummatous lesions involving organs or tissues.
Clinical Diagnosis of Syphilis:
Among various diagnostic modalities, definitive diagnosis of syphilis is made through visualizing the Treponema pallidum bacterium via darkfield microscopy, though rarely performed today. Nowadays, two tier-sequential testing algorithms, including nontreponemal tests followed by treponemal tests, confirm the treponema infection. Nontreponemal serological tests such as VDRL and RPR detect biomarkers released during cellular damage from syphilis spirochete infection. In contrast, treponemal tests such as FTA-ABS, TP-PA, various EIAs, chemiluminescence immunoassays, immunoblots, and rapid treponemal assays detect treponema pallidum antibodies IgM, and to a lesser degree treponema pallidum antibodies IgA that are specific for syphilis.
An Insight into syphilis specimens for research:
Discover your ideal research specimens at Central BioHub. Diving through our extensive inventory of research biospecimens will be fascinating for every biomedical researcher. Inculcating a fruitful supply relationship between certified biospecimen suppliers and buyers, Central BioHub acts as a connecting point of the virtual marketplace. Nested in Germany, Central BioHub brings you world-class human biospecimens ideal for life science research such as diagnostic research, clinical research, therapeutic research, or drug discovery. Our mission is to foster life science research to enhance the current medical care process to deliver the best patient care.
We provide you with an array of premium quality syphilis samples or syphilis infection samples for research obtained from voluntary donations of suspected or clinically diagnosed syphilis patients. Conforming with every standard of the Centers for Disease Control and Prevention (CDC), our partner biorepositories store syphilis biospecimens such as human serum, plasma (apheresis) samples at <-18 °C with strict maintenance of its viability. The syphilis blood samples are genuinely measured for various syphilis diagnostic parameters like anti-syphilis IgG, anti-syphilis IgM. Besides, treponemal antigen tests like chemiluminescence immunoassay for syphilis, Treponema pallidum particle agglutination, Treponema pallidum haemagglutination assay are also conducted. Our biospecimen inventory contains syphilis patient samples derived from ages, sex, and ethnicity, pregnant and non-pregnant individuals, with explicit annotation of relevant clinical data. Reach out to us for high quality, unbiased, resilient, cost-effective human biospecimens with complete support from scientific experts at every step of biospecimen procurement. Hurry up, order syphilis samples online for your next research project.
Explore advanced search options to procure syphilis samples for research, by clicking Clinical Diagnosis, ICD-10-CM Codes, and Laboratory Parameters.